Copper (Cu), a trace element, acting as cofactors in enzyme-catalyzed reactions. At high level, Cu is toxic to biological systems. Petroselinum crispum has benefit effects on human health due to polyphenol and flavonoid contents. This study aimed to assess the parslay oil (PO) preventive effects on copper sulfate haematological disruption induced in rats. PO were obtained by hydro-distillation and analyzed by gas chromatography-mass spectrometry (GC-MS). In vivo study was carried out on twenty eight male rats divided into four groups. Group (1): animals orally received copper sulfate in drinking water (2000 ppm), group (2): rats were orally administrated with PO (0.42 mg/ kg), group (3): animals received PO and copper sulfate and group (4) was kept as normal control. It was revealed that PO contained Pinene (37.83 % ), Apiol (15.40 %), Allyl tetramethoxybenzene (14.72 %) , β-Phellandrene (8.11 %), Bis(2-ethylhexyl) phthalate (7.47 % ), Myristicin( 7.46 %), trans-β-Ocimene (2.70 % ), β-Myrcene (1.00 %) , γ-Terpinene (0.57 %). Haematological study showed that Copper induced an increased blood platelet and a decreased red blood cell rates. Copper induced a macrocytic anemia and jaundice with a change in hematological parameters whereas it was reported PO almost recovered these variables. Parslay oil displayed preventive effects against Cu toxicity. Therefore, parsley oil may have a chelating effect on Cu showing less toxicity.

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