The aim of the present study was to evaluate the synergistic antibacterial effect between the Algerian honey and common antibiotics against Pseudomonas aeruginosa. Euphorbia, Thyme honey exhibited a potent antibacterial activity against Pseudomonas aeruginosa when used alone (the highest zone of inhibition (ZI) ,16mm at 80% (v/v); and at 90% (v/v), 13 mm respectively). The combined effect of honey and antibiotics against P.aeruginosa strains was more advantageous when compared to the antibiotic. Moreover (Amoxicillin-Acide clavulanic and Euphorbia honey) (Amoxicillin-Acide clavulanic and Thym honey) (amoxicillin and Thym honey) showed a great synergistic effect with FIC index 0,25 ; 0,25 ;0,15 respectively. The results revealed that euphorbia honey and thyme honey can be used separately or in synergistic combination with commonly used antibiotics.

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