Ponte Academic Journal Apr 2016, Volume 72, Issue 4 |
The Effects of Nonsurgical Periodontal Therapy on Serum Levels of Procalcitonin in Patients with Chronic and Aggressive Periodontitis Author(s): Canan Onder ,Sivge Kurgan, Nur Balci, Ayse Tayman, Zeliha Guney, Muhittin A. Serdar, Meral Gunhan J. Ponte - Apr 2016 - Volume 72 - Issue 4 doi: 10.21506/j.ponte.2016.4.8 Abstract: ABSTRACT
Background: The aim of this study was to evaluate the impact of non-surgical periodontal treatment on serum levels of ProCT and hsCRP in patients with chronic and aggressive periodontitis.
Materials and Methods: 20 patients with generalized aggressive periodontitis (GAgP), 22 patients with generalized chronic periodontitis (CP) and 21 systemically and periodontally healthy subjects (Control) were included in this study. Probing pocket depth (PPD), clinical attachment loss (CAL), gingival recession (GR) and bleeding on probing (BOP) were recorded at baseline and after 4 weeks of nonsurgical periodontal treatment. ProCT was assessed by Chemiluminescent assay and hsCRP was assessed by immunoturbidimetric assay in serum samples before and after 4 weeks.
Results: All clinical values were significantly higher in GAgP and CP groups compared to the control group and decreased significantly after treatment (p<0.001). Levels of ProCT were significantly higher in CP group compared to the control group (p<0.05). Levels of hsCRP were significantly higher in GAgP group compared to the control group (p<0.05). ProCT were significantly higher in CP group compared to the GAgP group (p<0.05). hsCRP were higher in GAgP group compared to the CP group (p=0,38). ProCT in GAgP group and hsCRP in CP group decreased significantly after non-surgical periodontal treatment (p<0.001)
Conclusions: ProCT might play a considerable role during periodontal inflammation and it may be recommended that an increased serum ProCT levels in patients with periodontal disease has the potential to be a biomarker for periodontal tissue breakdown.
Key Words: Chronic Periodontitis, Generalized Aggressive Periodontitis, Procalcitonin, hsCRP, Periodontal Treatment
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