Aim: Laparoscopic cholecystectomy (LC) is not so innocent operation in terms of increased thromboemboli risk when intraabdominal pressure,position of the patient during operation and patient-dependent risk factors were combined together.We aimed analyzing effects of LC operation performed at low pressure pneumoperitoneum. Materials an Method: Twenty-eight elective LC patients who were operated at 8mmHG CO2 pneumoperitoneum without thromboemboli prophylaxis from August 2015 to Feb 2016 at Lutfiye Nuri Burat Govermental Hospital General Surgery Clinic were analyzed retrospectively. Age,gender,ASA scores,BMI,comorbid diseases,duration of operation,hospital stay period,complications,PT,TT,INR,aPTT,D-dimer ve fibrinogen levels at preoperative one day ago,post operative 1st and 24th hours were recorded.Lower extremity Doppler USG was taken one day before and at 7th day of the operation in all the patients Results: Twenty (80%) of the patients were female and 5 (20%) were male.Mean age was 46.6±14.5 years and BMI was 28.1±4.0 percent.Twelve patients (48%) were in ASA I,12 (48%) in ASA II and one (4%) was in ASA III.The duration of 8 mmHg-pressured CO2 pneumoperitoneum was 34.6±8.3 minutes and total duration of the operation was 54.4±9.3 minutes.PT,TT,APTT,INR,D-dimer and fibrinogen levels shown significant difference at pre and post operative periods.(PT: 11.94,12.10,12.43,p<0.001;INR:1.0,1.02,1.04, p:0.005;aPTT:22.80,23.42,24.54,p:0.001;D-dimer:0.31,0.56,0.91,p<0.001;Fibrinogen:223.71,278.34, 355.67,p<0.001;and TT: 19.88,17.78,16.06,p<0.001 at pre and post operative 1st and 24th hours, respectively).Ultrasound and clinical exam revealed DVT in none of the patients. Conclusions:Though none of the patients developed DVT, Laparoscopic cholecystectomies at 8mmHg-pressured pneumoperitonum resulted in increased levels of PT,aPTT,INR,D-dimer and fibrinogen and decrease in TT levels.These results may be related with pressure effect of pneumoperitoneum causing decrease in portal vein flow and surgical trauma.

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