Background: This study aimed to investigate the relationship between serum uric acid (UA) \\r\\nlevels and long term survival after hospitalization for a severe exacerbation in chronic \\r\\nobstructive pulmonary disease (COPD) patients. \\r\\nMethods and Material: The study was designed as retrospective cohort study and performed \\r\\nintensive care unit (ICU). \\r\\nDatabase for COPD patients with an exacerbation with the diagnosis of acute respiratory \\r\\nfailure and required either noninvasive or invasive ventilation were reviewed and patients� \\r\\ndemographic and clinical characteristics and laboratory data were recorded. Patients were \\r\\ndivided into two groups according to their serum UA levels. \\r\\nStatistical analysis used: In the multivariable analysis, independent factors in predicting \\r\\nsurvival were investigated by Cox regression analysis with Backward selection using probable \\r\\nfactors determined in the previous analyses. \\r\\nResults: Among 103 COPD patients, the serum UA level was <6.9 mg/dL in 54 (52.4%) \\r\\npatients (low UA group) and ?6.9 mg/dL in 49 (47.6%) patients (high UA group). The groups \\r\\ndid not differ regarding 28-, 90-, 180-, and 365-day survival rates; the median duration of \\r\\nsurvival was 90 days in the low UA group and 51 days in the high UA group (p=0.584). The \\r\\nmultivariate Cox regression analysis revealed that high serum UA level (?6.9 mg/dL) was \\r\\nassociated with increased mortality risk in COPD patients hospitalized for acute exacerbation \\r\\n(hazard ratio=1.97, 95% confidence interval=1.10-3.51, p=0.022). \\r\\nConclusions: Serum UA level may be a beneficial biomarker in predicting mortality risk in \\r\\nCOPD patients with acute respiratory failure and required either noninvasive or invasive \\r\\nventilation.

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