logo
Ponte Academic Journal
Apr 2018, Volume 74, Issue 4

ANTI-PCA/YO AND ANTI-GAD LEVELS IN AUTISM SPECTRUM DISORDER AND ATTENTION DEFICIT HYPERACTIVITY DISORDER

Author(s): Cagatay Ugur ,Ozden Sukran Uneri, Esra Yurumez

J. Ponte - Apr 2018 - Volume 74 - Issue 4
doi: 10.21506/j.ponte.2018.4.4



Abstract:
Compelling evidences suggest that dysfunction in the cerebellar region of the brain plays has a significiant association with the etiology of autism spectrum disorders (ASD) and attention deficit hyperactivity disorders (ADHD). This study aims to investigate should there is the association between degeneration of the cerebellum and the etiologies of ASD and ADHD. The study recruited participants comprising of 40 children with ASD and 39 children with ADHD. 40 healthy children were recruited as the control group. The participants were analysed for an increase in anti-purkinje cell autoantibodies, called as Yo (anti-PCA/Yo) antibodies and anti-glutamic acid decarboxylase (GAD) antibody levels during cerebellar damage. Each child with ASD was evaluated using the autism behavior checklist (ABC), aberrant behavior checklist (AbBC) and childhood autism rating scale (CARS). The Conners’ Parent and Teacher Rating Scales-Revised Long Form (CPRS and CTRS) screening questionnaires were completed by the parents and teachers of children with ADHD. The anti-PCA/Yo and anti-GAD levels were determined using 10 ml venous samples from the participants. No significant sociodemographical differences were observed between the groups. Significant differences were found in the anti-Yo levels between children with ADHD and healthy subjects (p=0.002). Additionally, a positive correlation was observed between GAD levels and children age. This was the first study that evaluated levels of anti-Yo and anti-GAD levels in ADHD and ASD, and compared it to a control group. It found association between anti-Yo levels and ADHD. Further studies with larger samples and follow-up periods are necessary in order to investigate possible etiological factors among subjects with neuropsychiatric disorders.
Download full text:
Check if you have access through your login credentials or your institution