Gongronema latifolium Benth is a highly medicinal plant commonly used as spices and vegetable. The liver is an essential organ in the body whose main function is detoxification. It secretes enzymes whose level in blood accounts for the state of the liver. Thus, the effect of the ethanolic root extract of Gongronema on the serum levels of the liver enzymes aspartate transaminase (AST), alkaline phosphatase (ALP) and alanine transaminase (ALT) was investigated in male wistar rats. The rats were divided into 5 groups with 18 rats per group: Group A was the control, Group B, Group C, Group D and Group E were treated with 300mg|kg, 200mg|kg, 150mg|kg and 100mg|kg respectively for a period of 28 days. Blood was collected after 7 days of treatment and the liver marker enzymes were determined. There was an increase in the liver enzymes up till the 21st day then a decrease in the liver enzymes. This result suggests that the ethanolic root extract of Gongronema possesses both hepatotoxic and healing effects.

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