Cervical cancer is rated the second most common malignant tumor globally, and is an etiologically linked to human papillomavirus (HPV) infection. Interleukin-4 (IL-4) and Interleukin-10 are a cytokines with anti-inflammatory properties. The purpose of this study was to determine the relationship of difference alleles of IL-4 and IL-10 genes with passive smokers and use of oral contraceptives to risk of cervical cancer. We investigated the association of cervical cancer with two anti-inflammatory (IL-4, IL-10) cytokine genes in a case-control study. The study sample comprised 200 cases of cervical cancer and equal number of matched controls by variables number of tandem repeat (VNTR) and PCR-RFLP analysis. In this study, we observed Rp1/ Rp2 genotype of IL-4 borderline increase risk of developing cervix cancer (OR-1.3, 95%CI-0.45-3.64, p=0.8). In case of passive smokers, we also found marginal increase risk of cervical cancer with AC and combined AC+CC genotypes (OR-1.7, 95%CI-0.90-3.34, p=0.1 and OR-1.7, 95%CI- 0.90-3.17, p=0.1, respectively). However, non-significant association was observed between use of oral contraceptive and risk of cervical cancer with these two anti?inflammatory cytokines with different genotypes. The present study suggested in case of passive smokers having IL-4 Rp1/ Rp2 and IL-10 (AC) genotypes increased risk of developing cervix cancer in North Indian women.

Username
Password