Rickettsiae grow only intracellularly. The antibiotic susceptibility is assessed by plaque,dye uptake or IF assays. Rickettsiae are susceptible to doxycycline, thiamphenicol and fluroquinolones. Betalactams, aminoglycosides and cotrimoxazole are not active. Typhus group rickettsiae are susceptible to all macrolides,whereas the spotted fever are more resistant to rifampicin than the other rickettsiae. Rickettsiae felis is not susceptible to gentamicin, erythromycine, amoxicilline or cotrimoxazole. we present an overview of susceptibility of rickettsiae to antimicrobials

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