Upon completion of his master?s degree in medical genetics at the Federal Rio de Janeiro University in 2003, Dr Fonseca joined the Laborat?rio de Patologia Celular ? Departamento de Biologia Celular, of the Federal Fluminense University where he directed research in basic c?ncer research with translational research. This led to the development of invention of new approach for delivery drugs for malignant gliomas. He concludes PhD Thesis ?Exploratory study of monoterpene perillyl alcohol intranasal administration in patients with recurrent gliomas? in 2007. Dr Fonseca pioneered a new technology, intranasal administration of monoterpene perillyl alcohol. Intranasal administration of perillyl alcohol is not only an unique delivery method, but the use of perillyl alcohol as a novel chemotherapeutic agent inhibiting the ras pathway is extremely exciting. His results have demonstrated that intranasal perillyl alcohol will soon be able technique in armamentarium against malignant gliomas (Da Fonseca et al 2006; Da Fonseca et al 2006; Da Fonseca et al in press). It is expected that this work will lead development of methods for combine drugs with different therapeutic targets.

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