ABSTRACT Background:The aim of this study is to compare serum levels of IMA and CRP in patients with GAgP and healthy control individuals. Materials and Methods: 16 generalized aggressive periodontitis patients (GAgP; 8 female/ 8male) and 13 control (C; 7 female/6 male) individuals were including in this study.Probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) were recorded at six regions around every tooth. IMA levels in serum samples were evaluated by the albumin cobalt binding (ACB) test and hsCRP levels in serum samples were determined using immunoturbidimetric assays. Results:PPD, CAL and BOP values were significantly higher in the GAgP group compared to the control group (p<0.001). IMA and hsCRP levels were significantly higher in GAgP group compared to the control group(respectively, p=0.003 and p=0.046).Statistically significant positive correlations were observed between PPD, CAL, BOP values and serum hsCRP levels. A positive correlation was also observed between PPD, CAL values and serum IMA levels. Conclusions:This study showed the increased levels of serum IMA and hsCRP in the patients diagnosed with GAgP. Increased levels of IMA in patients with GAgP are due to the oxidative stress and it may suggest that serum IMA levels are valuable indicator for GAgP. Key Words: Generalized Aggressive PeriodontitisIschemia Modified Albumin and C-reactive protein

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