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Ponte Academic Journal
Feb 2021, Volume 77, Issue 2

RELATIONSHIP BETWEEN ACE GENE POLYMORPHISM AND CEREBRAL ISCHEMIC STROKE

Author(s): Suleyman Guler ,Sukran Guler Sanlıurfa training and research hospital radiology department,Mehmet ufuk aluçlu Dicle university neurology department

J. Ponte - Feb 2021 - Volume 77 - Issue 2
doi: 10.21506/j.ponte.2021.2.9



Abstract:
Background: Angiotensin converting enzyme (ACE) plays an essential role in the pathogenesis of vascular remodeling, atherosklerosis and hypertention. ACE Gene insertion/Deletion (I/D) Polymorphism has commonly been studied to illuminate the cerebral ischemic stroke as it has been in several other illnesses in recent years. The objective of this study was to evaluate the relationship between ACE gene I/D Polymorphism and cerebral ischemic stroke. Materials and methods: 54 patients with clinically and radiologically accepted to be cerebrovascular infarct but have no cerebrovascular disease in their background and 25 healthy people as control group accepted in Neurology Major Discipline of the Faculty of Medicine of Dicle University were included in our study. Full blood and biochemical values, stroke risk factors and ACE gene I/D polymorphisms were compared. Results: ACE D/D Ploymorphism was statistically found meaningfull in the patient group. Although lacunar infarcts frequency was elevated in ACE D/D Positivity, it was not concidered statistically meaningful. Hypertension and left ventricular hypertrophy in ACE D/D Patients was found statistically meaningfull, yet no significant correlation with ischemic heart story has been identified. Furthermore negative correlation was identified between carotid artery stenosis and the ACE D/D Gene polymorphism.
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