logo
Ponte Academic Journal
Apr 2018, Volume 74, Issue 4

NEUTROPHIL-LYMPHOCYTE RATIO AND PLATELET-LYMPHOCYTE RATIO AS MORTALITY PREDICTORS IN CRITICALLY ILL COPD PATIENTS

Author(s): Recai Ergun ,Begum Ergan

J. Ponte - Apr 2018 - Volume 74 - Issue 4
doi: 10.21506/j.ponte.2018.4.20



Abstract:
Introduction: Acute exacerbation of COPD (AECOPD) significantly increases the hospitalization in intensive care unit and also to mortality among patients with COPD. Acute predictors of mortality and morbidity following AECOPD can manipulate the treatment modality. We investigated the predictive value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients that are hospitalized due to AECOPD in intensive care unit (ICU). Material and methods: This study was performed between June 2011 to 2015 in an in ICU of a tertiary hospital by including the patients that are hospitalized in ICU and diagnosed as AECOPD. Results: The mortality rate was 34.8% (n=46). Apache-II score was higher and Glasgow coma scale (GCS) was lower in non-survivors. Lower FEV1% predicted is associated with mortality. Among co-morbidities, cardiac arrhythmia, renal failure and lung cancer were associated with increased mortality. Length of stay in the ICU stay time was longer in non-survivors. The mean values of NLR and PLR was greater in non-survivors but the differences were not statistically significant (p=0.655 and 0.261 respectively). The NLR was correlated with WBC and CRP (with WBC p<0.001 r=0.397 and with CRP p=0.028 r=0.190); but PLR has no correlation with WBC and CRP (with WBC p=0.164 r=0.122 and with CRP p=0.728 r=0.030). Discussion: NLR and PLR are the new biomarkers that are widely used prognostic markers in various diseases especially cardiovascular diseases but they are not good markers of mortality for patients that are hospitalized in intensive care unit due to AECOPD.
Download full text:
Check if you have access through your login credentials or your institution