Primary hypertension or essential hypertension is associated with high blood pressure. However, there is no known secondary prognosis with essential hypertension. Previous studies have shown that high blood pressure is linked to genetic factors and to a sedentary lifestyle. Recently, the interaction between angiotensin-converting enzyme (ACE) and adducing (ADE1) with blood pressure has been suggested. However, its significance and predisposition with biochemical factors were elusive. In this study, we have reported there is a strong association between genetic polymorphism of insertion/deletion (I/D) of ACE and G460T polymorphism of ADD1 gene and hypertension when both the parameters were taken into consideration. The study was conducted on genetically unrelated individuals from Punjab province of North India. We found that Odd ratio (OD) of ACE gene was 1.125 and of ADD1 was 0.409 respectively. However, we did not find any foreseen risk associated with single nucleotide polymorphism of studied genes and hypertension. We surmise that combination of genetic factors along with lifestyle play important role in determining arterial hypertension.

Username
Password