Background: Holistic health status is influenced by a multitude of factors, such as socio-economic status, cultural values, perceptions, attitudes, advanced information and technology, and the living and work environment. This study aims to examine the factors that predict the holistic health status of the Thai, Laotian, Vietnamese, and Cambodian peoples in the Greater Mekong Subregion (GMS) countries. Method: One thousand six hundred and seventy participants were recruited from major regions of Thailand, the Lao PDR, Vietnam, and Cambodia, and were selected using multistage random sampling. The study area provinces in each region of the GMS countries were compared according to similar geography and contexts. A self-reported holistic health status questionnaire was developed and a questionnaire assessing the people�s perceptions/attitudes concerning the factors affecting their holistic health was administered. Results: The major finding was that the factors predicting the holistic health of the people were the living and work environment and the availability of medical information and technology at their hospitals. Conclusion: This study initiates policy development in relation to the holistic health status of the people in the GMS countries, especially in terms of its predictors, in order to develop the quality of life of the people living there. The development of international health networks with public and private organizations in the future is recommended. The study of the provincial areas in each region of the GMS countries was compared according to similar geography and contexts.

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