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Ponte Academic Journal
Apr 2016, Volume 72, Issue 4

Actinomycetes mediated biogenic synthesis of metal nanoparticles: Progress and challenges

Author(s): Krishnan Kannabiran ,Manickavelu Manimaran

J. Ponte - Apr 2016 - Volume 72 - Issue 4
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Abstract:
Actinomycetes mediated biogenic synthesis of metal nanoparticles and their antagonistic activities against human microbial pathogens are well documented. Actinomycetes facilitate both intracellular and extracellular metal nanoparticles synthesis. Actinomycetes are efficient candidates for the production of polydisperse, stable and ultra-small size metal nanoparticles with significant antimicrobial activities. Actinomycetes derived secondary metabolites and new chemical entities are not extensively studied for the synthesis of newer nanoantimicrobials. The present review focuses on biological synthesis of metal nanoparticles from actinomycetes and the scope for exploring actinomycetes derived compounds as metal reducing agents for the synthesis of desired nanoparticles. In addition, the challenges ahead for the synthesis of biogenic metal nanoparticles with desired physiochemical properties such as ultra-small size, large surface to mass ratio, high reactivity and methods to evade unique interactions with biological systems are discussed to improve their chance as an alternative for the development of new therapeutic nanoantimicrobial agents.
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