The rationale of the research is caused by the fact that definition of the national border between Kazakhstan and Uzbekistan is a serious problem due to various reasons. The Central Asian Region acts as a buffer zone protecting the southern frontiers of the CIS and weakening of this section may threaten the stability of the situation. Due to this fact this article is aimed at revealing of the ways of cooperation and strengthening of the relationships between Kazakhstan and Uzbekistan. In this context exactly the relationships between the states acts as the basis of stability in Central Asia. The paper reveals cooperation in the sphere of foreign policy of the two key republics of Central Asia. The materials of the paper represent practical utility for further development of relationships between Uzbekistan and Kazakhstan as well as for the international relations in Central Asia. It seems to be reasonable for Kazakhstan and Uzbekistan, the two largest states in the region, to intensify their joint efforts for implementation of a series of integration projects in Central Asia with the purpose of achievement of stability in two- and multisided relations.

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