Objectives: The aim of this study was to examine the correlations between ghrelin and inflammatory and bone metabolic markers in differently aged female rats with periodontitis. \\r\\nMaterials and Methods: Thirty female Wistar rats (6 trial + 4 control in each group), were divided into the following 3 groups: a pubertal group, an adult group and postmenopausal group. The rats were anesthetised, and the first and second maxillary molars of the trial rats were ligatured. On the 21st day, intracardiac blood was collected under anaesthesia, and all rats were then sacrificed. Periodontal destruction was verified in maxillary radiographs. The blood samples were centrifuged at 3,000 rpm for 10 minutes, and the sera were tested to measure osteocalcin, osteoprotegerin, alkaline phosphatase, tumour necrosis factor alpha, interleukin 1 beta, acylated ghrelin, total ghrelin and soluble receptor activator of nuclear factor-kB ligands levels by ELISA. \\r\\nResults: Alkaline phosphatase levels were significantly higher in the trial rats of the pubertal group than in the control rats (p=0.033). In the postmenopausal group, ghrelin was positively correlated with interleukin 1 beta (r=0.708, p<0.05). Among all trial rats, the postmenopausal group had significantly higher acylated ghrelin levels than the other groups (p=0.001). Osteoprotegerin levels were significantly higher in the control rats than in the trial rats in the postmenopausal group (p=0.012). \\r\\nConclusions: We conclude that total ghrelin serum levels are correlated with IL-1 levels in reproductively senescent females. \\r\\nClinical Relevance: Ghrelin serum levels may be correlated with inflammatory cytokine levels.

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