Background To introduce our method for preventing shoulder pain which might occur following laparoscopic cholecystectomy and compare its efficiency to usual pneumoperitoneum evacuation method. Material and Methods: Sixty-four patients who underwent laparoscopic cholecystectomy (LC) at Diyarbakir Training and Research Hospital between 2011 and 2013 were included in the study. Classical pneumoperitoneum evacuation (CPE) was performed in 32 of them and pneumoperitoneum evacuation on Trendelenburg position (PETP) in remaining 32. The same standard-sized trocars and trocar-port sites were used in all the patients and LC was performed. Carbon dioxide gas was used for pneumoperitoneum which was insufflated at 14mm-Hg pressure and 2.5l/min flow-rate. The patients in whom conversion to open procedure were excluded. Operation periods and all shoulder pain sensation without caring its degree were recorded. Results There were 27 (84.3%) female and 5 (15.7%) male with the median of 43 (18-79) in CPE group. In PETP group, there were 29 (90.6%) female and 3 (9.4%) male patients, with the median of 52 (26-85) (p=0,115, p=0,458). None of the 32 patients in PETP group experienced shoulder pain in contrary to CPE group where 15 (46.8%) out of 32 patients experienced it (p=0,000). The mean operation period in CPE group was 55 (25-95) minutes and.5 (30-55) minutes PETP group51, respectively (p=0,755). None of the patients in both groups developed any method-related complication. Conclusion PETP is an efficient method which can be used easily in clinical practice without any complication.to prevent shoulder pain after laparoscopic cholecystectomy Keywords: Shoulder pain, laparoscopy, cholecystectomy, retained gas, carbon dioxide insufflation.

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