In Islam, sharia and akhlaq are very fundamental in its teaching and so is aqeedah. It is another significant foundation and the three are inter-linked to each other. Aqeedah forms the basis of iman (firm belief), hence if one of the components is missing, one’s iman is lost or later becomes unbalanced. The basis of this study was to address the prevalent issues of Islamic aqeedah, its concepts and their relevancy in the study of Malay genome in Malaysia. Besides, needs consideration were also discussed in implementing aqeedah-compliance index when conducting genome studies and researches so that they will not contradict the Islamic ethics and faith. This is also to avoid the destruction of humanity and also capable of providing a system that will solve the problems of humanity. In Malaysia, the studies of Malay genome have been administered by the Centre for Pharmacogenomics (iPROMISE), Faculty of Pharmacy, UiTM Puncak Alam Campus, Selangor Malaysia and the Faculty of Applied Science, UiTM Shah Alam Campus, Selangor Malaysia. Overall, researches on Malay genome have successfully developed a database of Malay genetic structure to help developing new drugs and vaccines, diagnosing diseases as well as providing links for these diseases to drugs commonly used for treating. Apparently, much effort has been made to determine the role of genetic variation and its imbalance patterns towards diseases.

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