Innovations and changes in medical systems stand out as new information technologies (IT) at an unprecedented pace. Hospitals try out to fit these changes by using advanced information technologies and they improve their services in time. For desired results of projects, applying �Change Management� is important as it consists a set of ideas, processes, and skills running human part of the change. This study investigates the processes (raising awareness, desire, knowledge, skill building and development), the tools (communication, participation, motivation, education, leadership, promotion), the factors (demographic, technological, economic, political, legal, competitive), the phases (past, present, future), the strategies (leading, expert, open to discussion, educative, proactive) of change management in hospital information systems. It shows the cultural, resistance, perception and behavior problems incurring when the change process starts and when it continues as well. Lastly, it lists a number of causes behind the resistance, and looks for precautions. Namely, this is a kind of research which focuses on the process of change management and the causes of users� resistance to change, and their precautions as developments in information technologies lead the use of health informatics in hospitals. Organizations like hospitals, which has a hierarchical structure, excessive discipline, solid job descriptions, seniority based on the power and authority principle, absence of communication channels, not sharing information experiences and top management commitment, not giving value to its employees ideas and opinions, weak leadership and the motivation, absent flexibility, not an effective learning system encounter resistance and never manages change management successfully.

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