The acetate model of ulcer formation was used to study the effect of mineral water from the Komsomolsky deposit of the Republic of Kalmykia on free radical homeostasis. The concentration of one of the main lipid oxidation products (LPO) - malonic dialdehyde (MDA) in liver, stomach and blood homogenates and concentration of antioxidant enzyme catalase in blood (serum and erythrocyte mass) of animals was determined. It is proved that the investigated mineral water does not prevent the significant development of acetate ulcers, that is, it does not possess a protective action against the ulcer in this model of ulceration. The effect of mineral water on the level of free radical oxidation in the modeling of acetate ulcers was determined by the level of the initial MDA, the rate of ascorbate-dependent and spontaneous lipid peroxidation in liver, stomach and blood. The antioxidant properties of mineral water in acetate ulcerogenesis were evaluated by its ability to influence the level of the enzyme catalase in the blood of the animal. It was found that the drinking of the analyzed mineral water by the animals with acetate ulcer did not affect the activity of serum catalase, but significantly (P <0.05) increased the activity of erythrocyte catalase without significantly reducing the rate of spontaneous and ascorbate-dependent LPO in the liver of animals.

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